Daytime rhythms have a great importance for sleep/waking cycle, body temperature, hormone levels, cognitive functions, and emotions.

According to the Frank et al. (2005) theory 1, biological rhythm disorders are associated with mood disorders and its relapses. Grandin et al. 2006 2 pointed out that irregular circadian rhythms lead to mood disorders in vulnerable individuals. Some authors drew attention to the relationship between behavior, cognition, affect and impairment of biological rhythms 3,4, others noted that inner rhythm is essential component of everyday human life 5. There are evidences that impairment of the biological rhythm predicts poor functioning and quality of life 6.

In fact, behavioral changes among psychiatric patients, are often observed before exacerbation. As an example - a sleep/waking cycle impairment, i.e., patients sleep in the daytime and, conversely, are active at night. The question is, how daily rhythms affect psychosis and how can we measure this effect?

The study aimed to determine the effect of rhythms in patients with acute psychosis and assess the frequency of problems, associated with maintaining the regularity of circadian rhythm in patients with acute schizophrenia.

For evaluation was used the BRIAN interview (Ukrainian version) - Biological Rhythm Interview of Assessment in Neuropsychiatry.

There are several tools for measuring circadian rhythms. Most of these questionnaires define only one element of circadian rhythms, such as sleep (Brief social rhythm scale or Epworth's sleepiness scale), and, unfortunately, does not take into account other elements needed for optimal circadian rhythm evaluation. Social rhythms include certain events at work, in public, leisure or physical activity. All of these components can affect circadian regularity, which is consistently associated with sleep disturbance. In this context, an adequate understanding of mental factors influence on biological rhythms and the development of specific tools for their evaluation is necessary. Therefore, the BRIAN interview was developed for the clinical evaluation of biological rhythm disturbances (sleep, social activity and nutrition structure) among patients with mental disorders 7.

The BRIAN is a simple questionnaire that is easy to use in a short time and suitable for clinical practice and research. The interview is also useful in clinical studies to assess circadian rhythm.

The five main domains of interviews are described below:

The BRIAN contains five areas that are listed above that can be scored between the maximum of 12 and 20 points for each. In particular, the interview evaluates the frequency of problems associated with maintaining the regularity of the circadian rhythm (for example: Do you have problems with falling asleep at regular time? How often? Elements are evaluated using a 4-point scale: (1) - never, (2) - rarely (3) - sometimes, (4) - often. The overall score is in the range from 1 to 84, the higher scores are associated with more severe circadian impairments.

The interview can be conducted by a psychologist or psychiatrist. Investigated time period refers to the last 15 days before the evaluation. The scores are given at each point. The researcher should evaluate the frequency of difficulties experienced by the patient in comparison with the same sex, age and socio-cultural status healthy person’s circadian rhythms.

The scale is currently available in English, Portuguese, and Spanish. We introduce the Ukrainian version (translated by Orlova N.).

The study lasted for six months and was conducted at the Acute Psychoses Department, TMO "Psychiatry," Kyiv. 60 patients with ICD-10 F20-29 diagnostic criteria were evaluated, most of them were diagnosed with acute schizophrenia (F 20.0). The mean patients’ age was 35.2 years. Evaluation was carried out in the first four days after hospitalization. To all respondents and their close relatives (in case of full legal capacity loss by the patient) were given informed consent before participation in the study. In general, patients did not have difficulties answering the questions.

Patients were rated in five main BRIAN domains: sleep, daytime and social activity, diet, and dominant rhythm or chronotype.

Below are the results of evaluation among patients with schizophrenia 8 (Fig. 1).

The total average score for the interview was 41 points (max. 84). In patients were noted sleep disorders, i.e., problems with falling or staying asleep. Daytime activity disturbances included difficulties in completing work, household, physical and sexual activities. Among negative diet patterns were noted inappropriately scheduled time, missed meals, excessive stimulants consumption (coffee, coca cola). Disturbances in social activities included difficulties in interactions with family, friends or spouse. The dominant rhythm or chronotype, defined for the last 12 months, was characterized by more vigorous work and overall activity at night. There was noted and inversion of day/night cycle.

The data for investigation of circadian activity, depending on the patients age, are presented in Figure 2 8.

A clear dependence of the circadian rhythm peculiarities, at all age patient groups, was determined. Among patients under the age of 40 (groups <30 and 31-40) prevailed the inverse day/night cycle, they were more active at night. In addition, these respondents experienced problems in interpersonal communications and relationships. 40-50-year-old patients noticed difficulties in their work, everyday life, and sexual relations. Patients aged 51 and older more often experienced marked day/night cycle alterations.

In the modern scientific world, the fundamental mechanisms of time "synchronization and sensation" by living organisms are actively discussed. Today it is already known that striatum is an important part of the basal ganglia associated with learning and motor function 9. Other studies have shown that a corpus striatum is necessary for the normal synchronization behavior among rats 10. The issue of subjective time perception mechanisms still present. And the search for its evaluation methods, especially among patients suffering from psychotic disorders, remains open and actively studied. In this publication, we made the first step in determining the possibility of using interviews in Ukrainian-speaking patients and obtained the first generalized conclusions from this sample. Our next step will include assessment of this scale’s reliability and validity in Ukrainian population.

The BRIAN is a simple clinical tool that allows you to evaluate the biological rhythms in mentally ill patients. The interview is useful for assessing the patient's mental condition during the last 15 days prior to admission. In this study BRIAN was translated and adapted for use in Ukrainian population. The interview has shown social activities disorganization, difficulties in communication and interpersonal relationships, alterations in day/night cycle in examined patients. Respondents did not have problems in answering questions. The next step is assessing the reliability and validity of BRAIN in Ukrainian population.